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Italian Sub Casserole is saucy, cheesy, a little spicy, and a whole lot delicious! Three types of cured meat, two types of cheese, lots of tomato sauce, and pillowy biscuit dough bake together to form a slice of deliciousness that you’ve never had before! It’s a cross between pizza, an Italian sub sandwich, and a pasta bake! Whatever it is, it’s going to be your family’s new favorite meal.

Ingredients for Italian Sub Casserole

• refrigerated biscuits
• mozzarella cheese
• provolone cheese
• deli ham
• pepperoni
• salami
• marinara sauce

How to Make Italian Sub Casserole

This is such an easy recipe. Like, there are 3 steps! That’s it!

First, cut each of the biscuits into six smaller pieces. Add the biscuit pieces to a large bowl, along with the rest of the ingredients, (except for 1/4 cup of the mozzarella cheese) and stir to combine.

Next, spray a large casserole dish with nonstick spray then pour in the combined ingredients. Sprinkle the rest of the mozzarella cheese over the top and cover with aluminum foil. Bake for 20 minutes, then discard the foil and bake for another 20-25 minutes.

Once the biscuits are cooked through and golden brown, serve and enjoy!

Recipe Notes

• If you want to half this recipe, you can bake it in an 8×8 pan. Just divide all the ingredients by half, including the biscuits. If you only use half of the biscuits, turn the other half into delicious Cinnamon Roll Biscuits!
• Use your favorite brand of canned refrigerated biscuits. I like Pillsbury Grands because I like the buttery flavor and how soft and pillowy they bake up.
• Swap out the provolone for more mozzarella, swiss, or your favorite white cheese. If you don’t love ham, you do all pepperoni and salami, or a combination of your favorite cured meats.

My Favorite Casserole Recipes

Black Bean Enchilada Casserole

Chicken Parmesan Casserole

Chicken Stuffing Casserole with Zucchini

Italian Sub Casserole

Recipe by Julia Pacheco

4.5 from 22 votes

Course: DinnerCuisine: ItalianDifficulty: Easy

Servings

4-5

servings

Prep time

5

minutes

Cooking time

45

minutes

Three types of cured meat, two types of cheese, lots of tomato sauce, and pillowy biscuit dough bake together to form a slice of deliciousness that you’ve never had before.

Cook Mode

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Ingredients

• 1 – 16.3 oz can refrigerated biscuits

• 1/2 cup mozzarella cheese, cubed or shredded

• 1/3 cup provolone cheese, sliced thin or shredded

• 1/3 cup deli ham, chopped

• 1/3 cup pepperoni, chopped

• 1/3 cup salami, chopped

• 1 cup marinara sauce

Directions

• Preheat oven to 375℉.
• Cut each of the biscuits into six smaller pieces. To a large bowl add all of the ingredients, except for 1/4 cup of the mozzarella cheese. Stir to combine.
• Spray a large casserole dish with nonstick spray then pour in the combined ingredients. Sprinkle the remaining cheese over the top and cover with aluminum foil.
• Bake for 20 minutes, then remove the foil and bake for an additional 20 to 25 minutes or until all of the biscuit pieces are cooked through. Enjoy!

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